Parallelizing Snakemake Rule

Sorry if this is a naive question, but I'm still trying to wrap my head around the intricacies of Snakemake. I have a directory containing a number of files that I want to apply a

Solution 1:

Currently, your workflow indeed consists in applying the "vep" rule only once, where it executes vep with all your inputs and outputs as arguments. I don't know how vep works, but it is likely either failing or not doing what you expect.

You should probably write your rule's input and output without expansion, and drive it using an "all" rule, that does the expand:

CHROMS = [str(c) for c inrange(1, 23)] + ["X"]


rule all:
    input:
        expand("data/vep/split/chr{chrom}.ann.vcf",
               chrom=CHROMS)

rule vep:
    input:
        "data/split/chr{chrom}.vcf"
    output:
        "data/vep/split/chr{chrom}.ann.vcf"
    shell:
        "vep ""{input} ""{output}"

To generate the desired input of the "all" rule, snakemake will determine how many times and how (i.e. with what value for the chrom wildcard) it needs to apply the "vep" rule.

Be sure to put the "all" rule before all other rules.